For JIRA, see https://confluence.atlassian.com/enterprise/jira-sizing-guide-461504623.html (there's no need to worry about your agents on top of your normal users - think of them as users who do some different stuff but don't add more or less load than a normal user)
For Confluence, https://confluence.atlassian.com/doc/server-hardware-requirements-guide-30736403.html is a good start
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Hi @Nic Brough -Adaptavist-, is it a best practice to put every application on one server
for example running JIRA / Confluence / Service Desk on NFS to the same server ?
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It might be. Sorry that this is a vague answer.
You can install the whole Atlassian stack on one machine, and see it work perfectly. The main problem with that is not "doing too much", but "single point of failure" and "We need a machine with enough resources to run all the things"
It is fine to run it all in one place. As long as that place can handle the load.
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